The 16-year-old's plight attracted worldwide attention after she had to wait for chemotherapy because of an abortion ban in the Dominican Republic.
Doctors were hesitant to give her chemotherapy because such treatment could terminate the pregnancy -- a violation of the Dominican Constitution, which bans abortion. Some 20 days after she was admitted to the hospital, she finally started receiving treatment.
She died Friday, a hospital official said.
At the time the treatment started, Rosa Hernandez, the girl's mother, said she tried to convince doctors and the Dominican government to make an exception so that her daughter's life could be saved.
"My daughter's life is first. I know that (abortion) is a sin and that it goes against the law ... but my daughter's health is first," Hernandez said.