The Mesolithic, a period that lasted from 10,000 to 5,000 years ago (between the Paleolithic and the Neolithic), ends with the advent of agriculture and livestock farming, coming from the Middle-East. The arrival of the Neolithic, with a carbohydrate-based diet and new pathogens transmitted by domesticated animals, entailed metabolic and immunological challenges that were reflected in genetic adaptations of post-Mesolithic populations. Among these is the ability to digest lactose, which La Braña individual could not do.

Lalueza-Fox states: "However, the biggest surprise was to discover that this individual possessed African versions in the genes that determine the light pigmentation of the current Europeans, which indicates that he had dark skin, although we can not know the exact shade".

CSIC researcher, who works at the Institute of Evolutionary Biology (a joint centre of CSIC and the University Pompeu Fabra (UPF), located in Barcelona, adds: "Even more surprising was to find that he possessed the genetic variations that produce blue eyes in current Europeans, resulting in a unique phenotype in a genome that is otherwise clearly northern European".