Got Cavities? Ancient Teeth Reveal Bacteria’s Evolution

Jul 26, 2014

By Stephanie Pappas

 

Ouch! The bacterium that causes toothaches has become more diverse over the course of human history, a new study finds.

Streptococcus mutans is a nasty little bacterium that lurks in the mouth, frequently causing tooth decay and cavities. Now, a new analysis of the bacteria’s DNA extracted from human teeth dating back to the Bronze Age reveals the bug has been mutating randomly over the years, becoming more diverse as the human population grows, perhaps because it has more mouths to fill.

The study of S. mutans is important, because understanding its development should provide clues as to what factors trigger its evolution, said study researcher Marc Simón, a professor at the Universitat Autònoma de Barcelona in Spain.

“Hopefully, it will allow us to predict how it will react under certain circumstances, and predicting its behavior might help us to fight it off in the future,” Simón wrote in an email to Live Science.

Tooth decay

S. mutans is a natural tenant of the mouth. It metabolizes sugars from food and excretes lactic acid. This lactic acid eats away at the mineralized enamel surface of the teeth, causing dental caries (Latin for “rot”), also known as cavities.

Dental cavities predate modern humans. They’ve been found in the mouth of the ancient human cousin Paranthropus robustus, a gorillalike primate that lived in Africa about 2 million years ago. But the fossil record shows an uptick in tooth decay coinciding with the shift from hunting to agriculture, particularly in Europe and North America. Increased consumption of carbohydrate-heavy fruits and cereals probably gave S. mutans more sugar to feast on.

In 2007, Simón and his research group managed to extract the first fragment of S. mutans’ DNA from the tooth of an ancient skeleton. In their new study, published today (July 22) in the journal Proceedings of the Royal Society B, the researchers examined S. mutans’  DNA from 10 human skeletons. The skeletons came from both Europe and America. The oldest was from Bronze Age Europe, an era that began in 3200 B.C. and stretched until 600 B.C. The youngest dated to the 1900s. The American skeletons were chosen from both before and after Americans encountered Europeans, in case that event caused any changes in tooth decay bacteria.

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