The Brain on Fear

Jun 30, 2015

by Ruth Williams

Animals respond to fear in predictable ways. A mouse confronted with danger is likely to either freeze in place or run for its life. But how this primal response is elicited in the brain has remained murky. A study in mice published in Science today (June 25) reveals specific neuronal wiring that runs between the eye and the amygdala—the emotion and decision-making center of the brain—that translates the sight of an advancing threat to the animal’s instinct to freeze or flee.

“One of the big challenges in neuroscience is to understand the relationship between molecules, cells, [and] synapses on one hand, and microcircuit function and behavior on the other,” said neuroscientist Peter Jonas of the Institute of Science and Technology in Klosterneuburg, Austria, who was not involved in the work. “It is nice to bridge these different levels and . . . this paper provides a nice example of how this is becoming possible.”

Fear behavior is critical for survival, and animals and humans use all their sensory inputs to detect, assess, and escape from life-threatening situations. In the case of visual threats, researchers have identified cells in the retina that respond to looming objects. Then, in the midbrain, a structure called the superior colliculus, which receives retinal neuron inputs, contributes to avoidance and defensive behavior. “However, the neuronal cells mediating these behaviors, and the circuits linking them to fear response remain unknown,” wrote Peng Cao of the Chinese Academy of Sciences in Beijing in an e-mail to The Scientist.

As a first step, Cao and his colleagues optogenetically stimulated all neurons in the superior colliculus of mice and found that this was sufficient to produce a fear response in the animals—the mice froze in place. The researchers then engineered specific subtypes of superior colliculus neurons to respond to light and found that stimulation of neurons expressing the calcium-binding protein parvalbumin (PV) produced a similar fear response—the mouse first attempted to escape but quickly froze. Stimulation of neurons expressing somatostatin (SST) or vasoactive intestinal peptide (VIP)—both peptide hormones—elicited no fear response at all.


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One comment on “The Brain on Fear”

  • What they seem to be saying is that some neurons are going from the eye to a part of the brain that deals with fear. It bypasses the visual center. This means that there is a sort of visual processor in the fear related circuits but we don’t see it since it is not part of the visual processor.

    Good stuff.



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