Rare form: Novel structures built from DNA emerge

Aug 4, 2015

Photo courtesy of The Biodesign Institute at Arizona State University

By Arizona State University

DNA, the molecular foundation of life, has new tricks up its sleeve. The four bases from which it is composed snap together like jigsaw pieces and can be artificially manipulated to construct endlessly varied forms in two and three dimensions. The technique, known as DNA origami, promises to bring futuristic microelectronics and biomedical innovations to market.

Hao Yan, a researcher at Arizona State University’s Biodesign Institute, has worked for many years to refine the technique. His aim is to compose new sets of design rules, vastly expanding the range of nanoscale architectures generated by the method. In new research, a variety of innovative nanoforms are described, each displaying unprecedented design control.

Yan is the Milton D. Glick Distinguished Chair of Chemistry and Biochemistry and directs Biodesign’s Center for Molecular Design and Biomimetics.

In the current study, complex nano-forms displaying arbitrary wireframe architectures have been created, using a new set of design rules. “Earlier design methods used strategies including parallel arrangement of DNA helices to approximate arbitrary shapes, but precise fine-tuning of DNA wireframe architectures that connect vertices in 3D space has required a new approach,” Yan says.


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