Several new studies, technologies provide insights into epilepsy control, surgical targets

Dec 5, 2015

Three studies to be presented at the American Epilepsy Society’s (AES) 69th Annual Meeting describe novel devices and technologies that could reshape current understanding of the complex mechanisms underpinning seizure development in the brain.

Two of the three studies unveil information about the neural networks that produce and propagate seizure activity, providing information that could help refine and target surgical interventions.

In the first study, (abstract 2.076|A.05) researchers from the University of Pennsylvania describe an array of transparent electrodes that can capture high-resolution images of neuronal activity in a live animal brain while simultaneously gathering electrophysiological information about neuron function.

The team previously demonstrated the technology in a single graphene electrode affixed to laboratory samples of brain tissue. According to the authors, graphene is an ideal material because of its flexibility, high electrical conductivity and opportunity to customize features on its surface.

Now, the researchers describe their use of novel nanofabrication techniques to construct graphene-based neural arrays for recording and stimulation. Experiments in live, anesthetized rats revealed that the electrodes are capable of recording epileptiform activity with a high signal-to-noise ratio, high spatial and temporal resolution, and without light-induced artifacts.

To continue reading the entire article and all three studies, click the name of the source below.

4 comments on “Several new studies, technologies provide insights into epilepsy control, surgical targets

  • This is the kind of reporting I love.

    No, not because my Niece has severe epilepsy.

    Because the underlying evidence is properly referenced, and because no-one is making any claim that is not fully supported by that evidence and because no-one is asking more of the conclusions than is warranted.

    Newspaper Editors please note. They won’t, of course, because that’s not what they’re paid to do.

    Be very, very, careful what you read. And remember that the World is defined by our collective conversation.

    Who is setting the agenda for your next conversation … ?

    Peace.



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  • This whole area of conformable bio-tolerant micro-electrodes is wonderful. Carbon continues to open all sorts of doors. Neural pacemakers promise very real therapies for all sorts of mental conditions with far lower side effects and effect depletion than drugs. The videos of controlling Parkinsonian tremors (pre-these new electrodes) are awesome.

    https://www.youtube.com/watch?v=mO3C6iTpSGo

    Brains work as well as they do by sitting on the edge of instability. It does though make them prone to tripping into a topical howl round of positive feedback. This condition can be easily detected in its early stages and a normalising beat added to slightly deafen receptors, turning the gain down.

    These are just the lower slopes of mental prosthesis. Graphene bio-tolerant electrodes will find there way into retinal and cochlear implants of much greater sophistication, even brain in to brain out modules like the hippocampus controlling the storage and valuation of memories.



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  • An extremely moving video; what courage he has, to render himself naked in the public square like that, and do so for everyones’ benefit!

    I found myself trying to imagine him as he might have been as a young child; or indeed, at any time before the disease struck.

    I found it cathartic.



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