• Photo credit: NIH via Flickr, CC by 2.0
    By Alexandra Ossola
    Thanks to the cocktail of drugs that make up antiretroviral therapy, HIV is no longer a death sentence. But there are downsides to antiretroviral […]

    • One other disadvantage of antiretrovirals. If the patient is not careful about taking every dose, the viral load can creep up and they can transmit it to others.

    • Looks like a really positive breakthrough. But it’s still got a long way to go, to get it to the people who need it.

    • Does it have to take out the entire HIV genome, or does it just take out a chunk, that means the virus is effective dead, but still leaving some junk HIV DNA remnants in the subject.

    • @david-r-allen

      Not sure if I have this right but as I understand it, a retrovirus like HIV puts code into its host’s DNA which acts as a sort of template for creating new viruses even if the infection has been cleared out. So this technique would edit the genome of the host to take out the but of code inserted rather than attacking the virus itself.

      Need a scientist to come and put me straight though

    • The idea of restriction endonucleases and their use has been around for decades. It would seem that finding the right one has proved elusive but it seems moderately likely that the molecular biology crew have constructed or repurposed the correct one at last. Great work.