• Stephanie wrote a new post, Epilogue to the Mouse’s Tale — on "epigenetics" 4 years, 2 months ago

    By Richard Dawkins and Yan Wong

    We saw in the Mouse’s Tale that the main differences between mice and men reside in the pattern of choosing genetic routines from the available toolbox. It is of even g […]

    • Thank You, enjoyed the read. Any chance the book: The Ancestor’s Tale A Pilgrimage to the Dawn of Life, gets further into the details of the ideas discussed in the Mouse’s Tale?

    • Short, sweet, and to the point; as usual.

    • But further, might not contingently useful epigenetic expressions of the genome, secured over a generation or two help in the production of a genome better able to sustain that expression?

      The useful epigenetic expression, non-agression/affection, say, possibly begin a complimentary change in the living environment (maybe equally epigenetic to start, or even cultural) that re-inforces that expression. You get fed deliberately perhaps or tolerated to pick parasites for your supper. The generation or two of sustained epi expression effect is like a flywheel, it provides a little momentum to carry over the behaviours when chance could break the spell of a useful mutuality or symbiosis, say? There will still be drop outs from this burgeoning new set of interactive and mutual behaviours and these supply the weak selection pressure to actually evolve the genome to make the useful expression more robust to short term noise. …Maybe?

    • For a taste of peanut butter, something both man and mouse enjoy, yet the other day the poor mouse sprung the trap while foraging and expressing its phenotype. Here is a brain fart that may have the same life span. Protein post-translational modification (PTM) creates a rich network of cells/organs/tissue, and I wonder to what degree, if any, PTM might act independently of the genome, managed by a protein feedback system that indirectly queues unshaped protein?